Ardmore, began with a plowed ditch for a Main Street in the summer of 1887 in Pickens county. It owes much of its existence to the construction of the Santa Fe Railroad, through the area during that time. It grew, as most frontier towns grew, over the years into a trading outpost for the region. In 1894, notorious outlaw William Dalton was gunned down by a posse as he tried to flee from his home in Ardmore. A large fire in 1895 destroyed much of the fledgling town, which forced residents to rebuild nearly the entire town. In the early 1900s, Ardmore became well known for its abundance of cotton-growing fields and eventually became known as the world's largest inland cotton port.